ULTRASOUND PHARMACY SPRAY-DRUG COATED STENT
Abstract: In recent years, the development and application of drug-eluting stents has received widespread attention and is considered as a revolution in the field of cardiovascular intervention. In this paper, the manufacturing technology of drug-coated stents in recent years is summarized, and the advantages and disadvantages of various processes are preliminarily evaluated. The application and advantages of our company (developed ultrasonic medical spraying equipment in drug-coated stents) are pointed out.
Key words: ultrasonic medical spraying equipment; drug-coated stent;
Cardiovascular disease is the number one killer in modern society. Interventional therapy is currently the main method of clinical treatment of coronary heart disease. About 1.5 million people in the world rely on intervention to save lives every year. However, the incidence of postoperative restenosis as high as 15% -16%, so far remains an unresolved problem, severely limited the long-term effects of interventional therapy and a wide range of applications. The emergence of drug-coated stent (also known as drug-eluting stent, drug-eluting stent), the combination of interventional therapy and local sustained release technology, set off a revolution in the field of cardiovascular intervention, its extraordinary efficacy makes other Intervention means dwarfs.
The coating process of drug-coated stents plays a key role in the success or failure of drug-coated stents. Nowadays, the coating technologies that have been developed are varied and the advantages of various processes are varied. As further research progresses, More coating technology to be developed and applied to bring more vitality to this area. The drug is coated on the surface of the stent with physical and chemical methods, of which the physical coating process is mainly used soaking and spraying, and the chemical method is mainly the use of electrochemical plating. These methods do not adhere to the surface of the stent coating adsorption, easy to fall off, the coating surface uneven, need repeated coating, resulting in thick edges and orange peel.
The development of the drug coating process is still in full swing, and various coating processes are continuously updated and improved. The newly developed process ultrasonic spraying equipment has been able to basically overcome the limitations of different processes. Ultrasonic medical spraying equipment is the use of electronic high-frequency vibration through the ceramic high frequency resonance ceramic atomization, the molecules of liquid water molecules scattered between the key to produce spray, without heating or other ancillary equipment. Compared with other ways, energy savings of 90%. In addition, the greater the frequency of ultrasonic spray atomization of the smaller the particles can reach 10 microns -25 micron particles, spray coating thin, uniform, does not appear bridging, thick edge and so on.
Ultrasonic medical spraying equipment developed by our company has the advantages of uniform, compact coating, less energy consumption, less pharmaceutical raw materials and simple operation compared with the existing electroplating, immersing and spraying equipment. Ultrasound medical spraying equipment indicates that cardiovascular interventional treatment has entered a New stage.
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